The N-Terminal, Polybasic Region Is Critical for Prion Protein Neuroprotective Activity

Several lines of evidence suggest that the normal form of the prion protein, PrP(C), exerts a neuroprotective activity against cellular stress or toxicity. One of the clearest examples of such activity is the ability of wild-type PrP(C) to suppress the spontaneous neurodegenerative phenotype of tran...

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Detalles Bibliográficos
Autores principales: Turnbaugh, Jessie A., Westergard, Laura, Unterberger, Ursula, Biasini, Emiliano, Harris, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183058/
https://www.ncbi.nlm.nih.gov/pubmed/21980526
http://dx.doi.org/10.1371/journal.pone.0025675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183058/
https://www.ncbi.nlm.nih.gov/pubmed/21980526
http://dx.doi.org/10.1371/journal.pone.0025675

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