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First-Step Mutations for Adaptation at Elevated Temperature Increase Capsid Stability in a Virus
The relationship between mutation, protein stability and protein function plays a central role in molecular evolution. Mutations tend to be destabilizing, including those that would confer novel functions such as host-switching or antibiotic resistance. Elevated temperature may play an important rol...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183071/ https://www.ncbi.nlm.nih.gov/pubmed/21980515 http://dx.doi.org/10.1371/journal.pone.0025640 |