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Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms

BACKGROUND: The protease-antiprotease hypothesis proposes that inflammatory cells and oxidative stress in chronic obstructive pulmonary disease (COPD) produce increased levels of proteolytic enzymes (neutrophil elastase, matrix metalloproteinases [MMP]) which contribute to destruction of parenchyma...

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Autores principales: Dalvi, Prashant S., Singh, Anil, Trivedi, Hiren R., Ghanchi, Feroz D., Parmar, Dinesh M., Mistry, Suresh D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183640/
https://www.ncbi.nlm.nih.gov/pubmed/21977068
http://dx.doi.org/10.4103/1817-1737.84777
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author Dalvi, Prashant S.
Singh, Anil
Trivedi, Hiren R.
Ghanchi, Feroz D.
Parmar, Dinesh M.
Mistry, Suresh D.
author_facet Dalvi, Prashant S.
Singh, Anil
Trivedi, Hiren R.
Ghanchi, Feroz D.
Parmar, Dinesh M.
Mistry, Suresh D.
author_sort Dalvi, Prashant S.
collection PubMed
description BACKGROUND: The protease-antiprotease hypothesis proposes that inflammatory cells and oxidative stress in chronic obstructive pulmonary disease (COPD) produce increased levels of proteolytic enzymes (neutrophil elastase, matrix metalloproteinases [MMP]) which contribute to destruction of parenchyma resulting in progressive decline in forced expiratory volume in one second. Doxycycline, a tetracycline analogue, possesses anti-inflammatory properties and inhibits MMP enzymes. OBJECTIVES: To assess the effect of 4 weeks doxycycline in a dose of 100 mg once a day in patients of moderate to severe COPD with stable symptoms. METHODS: In an interventional, randomized, observer-masked, parallel study design, the effect of doxycycline (100 mg once a day for 4 weeks) was assessed in patients of COPD having stable symptoms after a run-in period of 4 weeks. The study participants in reference group did not receive doxycycline. The parameters were pulmonary functions, systemic inflammation marker C-reactive protein (CRP), and medical research council (MRC) dyspnea scale. Use of systemic corticosteroids or antimicrobial agents was not allowed during the study period. RESULTS: A total of 61 patients completed the study (31 patients in doxycycline group and 30 patients in reference group). At 4 weeks, the pulmonary functions significantly improved in doxycycline group and the mean reduction in baseline serum CRP was significantly greater in doxycycline group as compared with reference group. There was no significant improvement in MRC dyspnea scale in both groups at 4 weeks. CONCLUSION: The anti-inflammatory and MMP-inhibiting property of doxycycline might have contributed to the improvement of parameters in this study.
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spelling pubmed-31836402011-10-05 Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms Dalvi, Prashant S. Singh, Anil Trivedi, Hiren R. Ghanchi, Feroz D. Parmar, Dinesh M. Mistry, Suresh D. Ann Thorac Med Original Article BACKGROUND: The protease-antiprotease hypothesis proposes that inflammatory cells and oxidative stress in chronic obstructive pulmonary disease (COPD) produce increased levels of proteolytic enzymes (neutrophil elastase, matrix metalloproteinases [MMP]) which contribute to destruction of parenchyma resulting in progressive decline in forced expiratory volume in one second. Doxycycline, a tetracycline analogue, possesses anti-inflammatory properties and inhibits MMP enzymes. OBJECTIVES: To assess the effect of 4 weeks doxycycline in a dose of 100 mg once a day in patients of moderate to severe COPD with stable symptoms. METHODS: In an interventional, randomized, observer-masked, parallel study design, the effect of doxycycline (100 mg once a day for 4 weeks) was assessed in patients of COPD having stable symptoms after a run-in period of 4 weeks. The study participants in reference group did not receive doxycycline. The parameters were pulmonary functions, systemic inflammation marker C-reactive protein (CRP), and medical research council (MRC) dyspnea scale. Use of systemic corticosteroids or antimicrobial agents was not allowed during the study period. RESULTS: A total of 61 patients completed the study (31 patients in doxycycline group and 30 patients in reference group). At 4 weeks, the pulmonary functions significantly improved in doxycycline group and the mean reduction in baseline serum CRP was significantly greater in doxycycline group as compared with reference group. There was no significant improvement in MRC dyspnea scale in both groups at 4 weeks. CONCLUSION: The anti-inflammatory and MMP-inhibiting property of doxycycline might have contributed to the improvement of parameters in this study. Medknow Publications 2011 /pmc/articles/PMC3183640/ /pubmed/21977068 http://dx.doi.org/10.4103/1817-1737.84777 Text en Copyright: © Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dalvi, Prashant S.
Singh, Anil
Trivedi, Hiren R.
Ghanchi, Feroz D.
Parmar, Dinesh M.
Mistry, Suresh D.
Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
title Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
title_full Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
title_fullStr Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
title_full_unstemmed Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
title_short Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
title_sort effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183640/
https://www.ncbi.nlm.nih.gov/pubmed/21977068
http://dx.doi.org/10.4103/1817-1737.84777
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