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Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management

Omega-3 polyunsaturated fatty acids (PUFAs) from fish and fish oils appear to protect against coronary heart disease: their dietary intake is in fact inversely associated to cardiovascular disease morbidity/mortality in population studies. Recent evidence suggests that at least part of their heart p...

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Detalles Bibliográficos
Autores principales: BORGHI, CLAUDIO, CICERO, ARRIGO F.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184661/
https://www.ncbi.nlm.nih.gov/pubmed/21977258
http://dx.doi.org/10.4081/hi.2006.98
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author BORGHI, CLAUDIO
CICERO, ARRIGO F.G.
author_facet BORGHI, CLAUDIO
CICERO, ARRIGO F.G.
author_sort BORGHI, CLAUDIO
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description Omega-3 polyunsaturated fatty acids (PUFAs) from fish and fish oils appear to protect against coronary heart disease: their dietary intake is in fact inversely associated to cardiovascular disease morbidity/mortality in population studies. Recent evidence suggests that at least part of their heart protective effect is mediated by a relatively small but significant decrease in blood pressure level. In fact, omega-3 PUFAs exhibit wide-ranging biological actions that include regulating both vasomotor tone and renal sodium excretion, partly competing with omega-6 PUFAs for common metabolic enzymes and thereby decreasing the production of vasocostrincting rather than vasodilating and anti-inflammatory eicosanoids. PUFAs also reduce angiotensin-converting enzyme (ACE) activity, angiotensin II formation, TGF-beta expression, enhance eNO generation and activate the parasympathetic nervous system. The final result is improved vasodilation and arterial compliance of both small and large arteries. Preliminary clinical trials involving dyslipidemic patients, diabetics and elderly subjects, as well as normotensive and hypertensive subjects confirm this working hypothesis. Future research will clarify if PUFA supplementation could improve the antihypertensive action of specific blood pressure lowering drug classes and of statins.
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spelling pubmed-31846612011-10-05 Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management BORGHI, CLAUDIO CICERO, ARRIGO F.G. Heart Int Article Omega-3 polyunsaturated fatty acids (PUFAs) from fish and fish oils appear to protect against coronary heart disease: their dietary intake is in fact inversely associated to cardiovascular disease morbidity/mortality in population studies. Recent evidence suggests that at least part of their heart protective effect is mediated by a relatively small but significant decrease in blood pressure level. In fact, omega-3 PUFAs exhibit wide-ranging biological actions that include regulating both vasomotor tone and renal sodium excretion, partly competing with omega-6 PUFAs for common metabolic enzymes and thereby decreasing the production of vasocostrincting rather than vasodilating and anti-inflammatory eicosanoids. PUFAs also reduce angiotensin-converting enzyme (ACE) activity, angiotensin II formation, TGF-beta expression, enhance eNO generation and activate the parasympathetic nervous system. The final result is improved vasodilation and arterial compliance of both small and large arteries. Preliminary clinical trials involving dyslipidemic patients, diabetics and elderly subjects, as well as normotensive and hypertensive subjects confirm this working hypothesis. Future research will clarify if PUFA supplementation could improve the antihypertensive action of specific blood pressure lowering drug classes and of statins. PAGEPress Publications 2006-09-30 /pmc/articles/PMC3184661/ /pubmed/21977258 http://dx.doi.org/10.4081/hi.2006.98 Text en © Wichtig Editore, 2006
spellingShingle Article
BORGHI, CLAUDIO
CICERO, ARRIGO F.G.
Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management
title Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management
title_full Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management
title_fullStr Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management
title_full_unstemmed Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management
title_short Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management
title_sort omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184661/
https://www.ncbi.nlm.nih.gov/pubmed/21977258
http://dx.doi.org/10.4081/hi.2006.98
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