Exploiting CpG Hypermutability to Identify Phenotypically Significant Variation Within Human Protein-Coding Genes

The CpG dinucleotide is disproportionately represented in human genetic variation due to the hypermutability of 5-methyl-cytosine (5mC). We exploit this hypermutability and a novel codon substitution model to identify candidate functionally important exonic nucleotides. Population genetic theory sug...

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Detalles Bibliográficos
Autores principales: Ying, Hua, Huttley, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184784/
https://www.ncbi.nlm.nih.gov/pubmed/21398426
http://dx.doi.org/10.1093/gbe/evr021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184784/
https://www.ncbi.nlm.nih.gov/pubmed/21398426
http://dx.doi.org/10.1093/gbe/evr021

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