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Exploiting CpG Hypermutability to Identify Phenotypically Significant Variation Within Human Protein-Coding Genes
The CpG dinucleotide is disproportionately represented in human genetic variation due to the hypermutability of 5-methyl-cytosine (5mC). We exploit this hypermutability and a novel codon substitution model to identify candidate functionally important exonic nucleotides. Population genetic theory sug...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184784/ https://www.ncbi.nlm.nih.gov/pubmed/21398426 http://dx.doi.org/10.1093/gbe/evr021 |