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Improving a Natural CaMKII Inhibitor by Random and Rational Design
BACKGROUND: CaM-KIIN has evolved to inhibit stimulated and autonomous activity of the Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) efficiently, selectively, and potently (IC50 ∼100 nM). The CN class of peptides, derived from the inhibitory region of CaM-KIIN, provides powerful new to...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184957/ https://www.ncbi.nlm.nih.gov/pubmed/21984908 http://dx.doi.org/10.1371/journal.pone.0025245 |