Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription

Autoimmune regulator (AIRE) is a transcription factor that induces the expression of a large subset of otherwise strictly tissue restricted antigens in medullary thymic epithelial cells, thereby enabling their presentation to developing T cells for negative selection. Mutations in AIRE lead to autoi...

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Detalles Bibliográficos
Autores principales: Žumer, Kristina, Plemenitaš, Ana, Saksela, Kalle, Peterlin, B. Matija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185428/
https://www.ncbi.nlm.nih.gov/pubmed/21724609
http://dx.doi.org/10.1093/nar/gkr527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185428/
https://www.ncbi.nlm.nih.gov/pubmed/21724609
http://dx.doi.org/10.1093/nar/gkr527

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