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STEME: efficient EM to find motifs in large data sets

MEME and many other popular motif finders use the expectation–maximization (EM) algorithm to optimize their parameters. Unfortunately, the running time of EM is linear in the length of the input sequences. This can prohibit its application to data sets of the size commonly generated by high-throughp...

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Detalles Bibliográficos
Autores principales: Reid, John E., Wernisch, Lorenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185442/
https://www.ncbi.nlm.nih.gov/pubmed/21785132
http://dx.doi.org/10.1093/nar/gkr574