RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis

RNA replicons are derived from either positive- or negative-strand RNA viruses. They represent disabled virus vectors that are not only avirulent, but also unable to revert to virulence. Due to autonomous RNA replication, RNA replicons are able to drive high level, cytosolic expression of recombinan...

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Detalles Bibliográficos
Autor principal: Zimmer, Gert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185613/
https://www.ncbi.nlm.nih.gov/pubmed/21994644
http://dx.doi.org/10.3390/v2020413
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author Zimmer, Gert
author_facet Zimmer, Gert
author_sort Zimmer, Gert
collection PubMed
description RNA replicons are derived from either positive- or negative-strand RNA viruses. They represent disabled virus vectors that are not only avirulent, but also unable to revert to virulence. Due to autonomous RNA replication, RNA replicons are able to drive high level, cytosolic expression of recombinant antigens stimulating both the humoral and the cellular branch of the immune system. This review provides an update on the available literature covering influenza virus vaccines based on RNA replicons. The pros and cons of these vaccine strategies will be discussed and future perspectives disclosed.
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spelling pubmed-31856132011-10-12 RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis Zimmer, Gert Viruses Review RNA replicons are derived from either positive- or negative-strand RNA viruses. They represent disabled virus vectors that are not only avirulent, but also unable to revert to virulence. Due to autonomous RNA replication, RNA replicons are able to drive high level, cytosolic expression of recombinant antigens stimulating both the humoral and the cellular branch of the immune system. This review provides an update on the available literature covering influenza virus vaccines based on RNA replicons. The pros and cons of these vaccine strategies will be discussed and future perspectives disclosed. Molecular Diversity Preservation International (MDPI) 2010-01-29 /pmc/articles/PMC3185613/ /pubmed/21994644 http://dx.doi.org/10.3390/v2020413 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Zimmer, Gert
RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis
title RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis
title_full RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis
title_fullStr RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis
title_full_unstemmed RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis
title_short RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis
title_sort rna replicons - a new approach for influenza virus immunoprophylaxis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185613/
https://www.ncbi.nlm.nih.gov/pubmed/21994644
http://dx.doi.org/10.3390/v2020413
work_keys_str_mv AT zimmergert rnarepliconsanewapproachforinfluenzavirusimmunoprophylaxis

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