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RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications
The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell an...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185779/ https://www.ncbi.nlm.nih.gov/pubmed/21994761 http://dx.doi.org/10.3390/v3060906 |
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author | Ireton, Reneé C. Gale, Michael |
author_facet | Ireton, Reneé C. Gale, Michael |
author_sort | Ireton, Reneé C. |
collection | PubMed |
description | The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell and activate a cascade of antiviral responses including the induction of type I interferons, inflammasome activation, and expression of proinflammatory cytokines and chemokines. This review provides a brief overview of RLR function, ligand interactions, and downstream signaling events with an expanded discussion on the therapeutic potential of targeting RLRs for immune stimulation and treatment of virus infection. |
format | Online Article Text |
id | pubmed-3185779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31857792011-10-12 RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications Ireton, Reneé C. Gale, Michael Viruses Review The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell and activate a cascade of antiviral responses including the induction of type I interferons, inflammasome activation, and expression of proinflammatory cytokines and chemokines. This review provides a brief overview of RLR function, ligand interactions, and downstream signaling events with an expanded discussion on the therapeutic potential of targeting RLRs for immune stimulation and treatment of virus infection. Molecular Diversity Preservation International (MDPI) 2011-06-23 /pmc/articles/PMC3185779/ /pubmed/21994761 http://dx.doi.org/10.3390/v3060906 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Ireton, Reneé C. Gale, Michael RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications |
title | RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications |
title_full | RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications |
title_fullStr | RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications |
title_full_unstemmed | RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications |
title_short | RIG-I Like Receptors in Antiviral Immunity and Therapeutic Applications |
title_sort | rig-i like receptors in antiviral immunity and therapeutic applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185779/ https://www.ncbi.nlm.nih.gov/pubmed/21994761 http://dx.doi.org/10.3390/v3060906 |
work_keys_str_mv | AT iretonreneec rigilikereceptorsinantiviralimmunityandtherapeuticapplications AT galemichael rigilikereceptorsinantiviralimmunityandtherapeuticapplications |