Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V

The cold-sensitive single-residue mutation of glycine 680 in the reactive thiol region of Dictyostelium discoideum myosin-2 or the corresponding conserved glycine in other myosin isoforms has been reported to interfere with motor function. Here we present the x-ray structures of myosin motor domain...

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Detalles Bibliográficos
Autores principales: Preller, Matthias, Bauer, Stefanie, Adamek, Nancy, Fujita-Becker, Setsuko, Fedorov, Roman, Geeves, Michael A., Manstein, Dietmar J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186370/
https://www.ncbi.nlm.nih.gov/pubmed/21841195
http://dx.doi.org/10.1074/jbc.M111.265298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186370/
https://www.ncbi.nlm.nih.gov/pubmed/21841195
http://dx.doi.org/10.1074/jbc.M111.265298

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