Cargando…
Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models
Mitochondrial cytochrome c (cyt. c) release and caspase activation are often impaired in tumors with Bcl-2 overexpression or Bax and Bak-defective status. Direct triggering of cell death downstream of Bax and Bak is an attractive strategy to kill such cancers. Small molecule compounds capable of dir...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186908/ https://www.ncbi.nlm.nih.gov/pubmed/21900958 http://dx.doi.org/10.1038/cddis.2011.90 |