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Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models

Mitochondrial cytochrome c (cyt. c) release and caspase activation are often impaired in tumors with Bcl-2 overexpression or Bax and Bak-defective status. Direct triggering of cell death downstream of Bax and Bak is an attractive strategy to kill such cancers. Small molecule compounds capable of dir...

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Detalles Bibliográficos
Autores principales:	Seervi, M, Joseph, J, Sobhan, P K, Bhavya, B C, Santhoshkumar, T R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186908/ https://www.ncbi.nlm.nih.gov/pubmed/21900958 http://dx.doi.org/10.1038/cddis.2011.90

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