Formation of a N(2)-dG:N(2)-dG Carbinolamine DNA Cross-link by the trans-4-Hydroxynonenal-Derived (6S,8R,11S) 1,N(2)-dG Adduct

[Image: see text] Michael addition of trans-4-hydroxynonenal (HNE) to deoxyguanosine yields diastereomeric 1,N(2)-dG adducts in DNA. When placed opposite dC in the 5′-CpG-3′ sequence, the (6S,8R,11S) diastereomer forms a N(2)-dG:N(2)-dG interstrand cross-link [Wang, H.; Kozekov, I. D.; Harris, T. M....

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Detalles Bibliográficos
Autores principales: Huang, Hai, Wang, Hao, Kozekova, Albena, Rizzo, Carmelo J., Stone, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187658/
https://www.ncbi.nlm.nih.gov/pubmed/21916419
http://dx.doi.org/10.1021/ja205145q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187658/
https://www.ncbi.nlm.nih.gov/pubmed/21916419
http://dx.doi.org/10.1021/ja205145q

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