Thiazolidinedione-Based PI3Kα Inhibitors: An Analysis of Biochemical and Virtual Screening Methods

A series of synthesized and commercially available compounds were assessed against PI3Kα for in vitro inhibitory activity and the results compared to binding calculated in silico. Using published crystal structures of PI3Kγ and PI3Kδ co-crystallized with inhibitors as a template, docking was able to...

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Detalles Bibliográficos
Autores principales: Pinson, Jo-Anne, Schmidt-Kittler, Oleg, Zhu, Jiuxiang, Jennings, Ian G, Kinzler, Kenneth W, Vogelstein, Bert, Chalmers, David K, Thompson, Philip E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187668/
https://www.ncbi.nlm.nih.gov/pubmed/21360822
http://dx.doi.org/10.1002/cmdc.201000467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187668/
https://www.ncbi.nlm.nih.gov/pubmed/21360822
http://dx.doi.org/10.1002/cmdc.201000467

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