Polytopic membrane protein folding at L17 in the ribosome tunnel initiates cyclical changes at the translocon

Multi-spanning membrane protein loops are directed alternately into the cytosol or ER lumen during cotranslational integration. Nascent chain exposure is switched after a newly synthesized transmembrane segment (TMS) enters the ribosomal tunnel. FRET measurements revealed that each TMS is initially...

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Detalles Bibliográficos
Autores principales: Lin, Pen-Jen, Jongsma, Candice G., Pool, Martin R., Johnson, Arthur E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187706/
https://www.ncbi.nlm.nih.gov/pubmed/21949410
http://dx.doi.org/10.1083/jcb.201103118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187706/
https://www.ncbi.nlm.nih.gov/pubmed/21949410
http://dx.doi.org/10.1083/jcb.201103118

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