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Polytopic membrane protein folding at L17 in the ribosome tunnel initiates cyclical changes at the translocon
Multi-spanning membrane protein loops are directed alternately into the cytosol or ER lumen during cotranslational integration. Nascent chain exposure is switched after a newly synthesized transmembrane segment (TMS) enters the ribosomal tunnel. FRET measurements revealed that each TMS is initially...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187706/ https://www.ncbi.nlm.nih.gov/pubmed/21949410 http://dx.doi.org/10.1083/jcb.201103118 |