Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity

Protein kinase D (PKD) is a novel family of serine/threonine kinases regulated by diacylglycerol, which is involved in multiple cellular processes and various pathological conditions. The limited number of cell-active, selective inhibitors has historically restricted biochemical and pharmacological...

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Detalles Bibliográficos
Autores principales: Sharlow, Elizabeth R., Mustata Wilson, Gabriela, Close, David, Leimgruber, Stephanie, Tandon, Manuj, Reed, Robyn B., Shun, Tong Ying, Wang, Q. Jane, Wipf, Peter, Lazo, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187749/
https://www.ncbi.nlm.nih.gov/pubmed/21998636
http://dx.doi.org/10.1371/journal.pone.0025134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187749/
https://www.ncbi.nlm.nih.gov/pubmed/21998636
http://dx.doi.org/10.1371/journal.pone.0025134

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