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Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity
Protein kinase D (PKD) is a novel family of serine/threonine kinases regulated by diacylglycerol, which is involved in multiple cellular processes and various pathological conditions. The limited number of cell-active, selective inhibitors has historically restricted biochemical and pharmacological...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187749/ https://www.ncbi.nlm.nih.gov/pubmed/21998636 http://dx.doi.org/10.1371/journal.pone.0025134 |