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3D Mapping of the SPRY2 Domain of Ryanodine Receptor 1 by Single-Particle Cryo-EM

The type 1 skeletal muscle ryanodine receptor (RyR1) is principally responsible for Ca(2+) release from the sarcoplasmic reticulum and for the subsequent muscle contraction. The RyR1 contains three SPRY domains. SPRY domains are generally known to mediate protein-protein interactions, however the lo...

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Detalles Bibliográficos
Autores principales: Perálvarez-Marín, Alex, Tae, HanShen, Board, Philip G., Casarotto, Marco G., Dulhunty, Angela F., Samsó, Montserrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187800/
https://www.ncbi.nlm.nih.gov/pubmed/21998699
http://dx.doi.org/10.1371/journal.pone.0025813