Cargando…

Chronic Effects of Palmitate Overload on Nutrient-Induced Insulin Secretion and Autocrine Signalling in Pancreatic MIN6 Beta Cells

BACKGROUND: Sustained exposure of pancreatic β cells to an increase in saturated fatty acids induces pleiotropic effects on β-cell function, including a reduction in stimulus-induced insulin secretion. The objective of this study was to investigate the effects of chronic over supply of palmitate upo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watson, Maria L., Macrae, Katherine, Marley, Anna E., Hundal, Harinder S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187833/ https://www.ncbi.nlm.nih.gov/pubmed/21998735 http://dx.doi.org/10.1371/journal.pone.0025975

Ejemplares similares

Mitochondrial Ca(2+) Uptake Relieves Palmitate-Induced Cytosolic Ca(2+) Overload in MIN6 Cells
por: Ly, Luong Dai, et al.
Publicado: (2020)

Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells
por: Cha, Seon-Heui, et al.
Publicado: (2018)

Determining the insulin secretion potential for certain specific G-protein coupled receptors in MIN6 pancreatic beta cells
por: GENÇOĞLU, Hasan, et al.
Publicado: (2019)

ATP is an essential autocrine factor for pancreatic β‐cell signaling and insulin secretion
por: Hauke, Sebastian, et al.
Publicado: (2022)

Insulin secretion assays in an engineered MIN6 cell line
por: Yang, Liu, et al.
Publicado: (2023)

Ginsenoside Rg3 Suppresses Palmitate-Induced Apoptosis in MIN6N8 Pancreatic β-Cells
por: Kim, Kyong, et al.
Publicado: (2010)

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells
por: Yaluri, Nagendra, et al.
Publicado: (2015)

Functional Analysis of Novel Candidate Regulators of Insulin Secretion in the MIN6 Mouse Pancreatic β Cell Line
por: Kobayashi, Masaki, et al.
Publicado: (2016)

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets
por: Kato, Toyonori, et al.
Publicado: (2008)

Growth of MIN-6 Cells on Salmon Fibrinogen Scaffold Improves Insulin Secretion
por: Laidmäe, Ivo, et al.
Publicado: (2022)

Palmitate is not an effective fuel for pancreatic islets and amplifies insulin secretion independent of calcium release from endoplasmic reticulum
por: Kuok, Iok Teng, et al.
Publicado: (2019)

Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells
por: Vong, Chi Teng, et al.
Publicado: (2016)

Nutrient Regulation of Insulin Secretion
por: Creutzfeldt, W.
Publicado: (1993)

Drp1 Overexpression Decreases Insulin Content in Pancreatic MIN6 Cells
por: Kabra, Uma D., et al.
Publicado: (2022)

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading
por: Nisr, Raid B., et al.
Publicado: (2019)

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells
por: Arous, Caroline, et al.
Publicado: (2021)

Microarray Analysis of Novel Candidate Genes Responsible for Glucose-Stimulated Insulin Secretion in Mouse Pancreatic β Cell Line MIN6
por: Yamato, Eiji, et al.
Publicado: (2013)

Novel I(1)-Imidazoline Agonist S43126 Augment Insulin Secretion in Min6 Cells
por: Tesfai, Jerusalem, et al.
Publicado: (2012)

Glucose, adrenaline and palmitate antagonistically regulate insulin and glucagon secretion in human pseudoislets
por: Lorza-Gil, Estela, et al.
Publicado: (2019)

Mitochondrial Substrate Availability and Its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signaling in Skeletal Muscle
por: Lipina, Christopher, et al.
Publicado: (2013)

Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion
por: Sedgeman, Leslie R., et al.
Publicado: (2019)

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
por: Tunaru, Sorin, et al.
Publicado: (2018)

High Passage MIN6 Cells Have Impaired Insulin Secretion with Impaired Glucose and Lipid Oxidation
por: Cheng, Kim, et al.
Publicado: (2012)

Islet Stellate Cells Regulate Insulin Secretion via Wnt5a in Min6 Cells
por: Xu, Wei, et al.
Publicado: (2020)

Autocrine Extra-Pancreatic Trypsin 3 Secretion Promotes Cell Proliferation and Survival in Esophageal Adenocarcinoma
por: Han, Song, et al.
Publicado: (2013)

SPARC promotes pancreatic cancer cell proliferation and migration through autocrine secretion into the extracellular milieu
por: Pan, Kehua, et al.
Publicado: (2021)

UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid
por: Sargsyan, Ernest, et al.
Publicado: (2011)

Insulin-producing cells could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells
por: Shi, Qiping, et al.
Publicado: (2013)

An adiponectin-S1P autocrine axis protects skeletal muscle cells from palmitate-induced cell death
por: Botta, Amy, et al.
Publicado: (2020)

Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion
por: Sol, E-ri M, et al.
Publicado: (2009)

Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis
por: Lin, Xiaojie, et al.
Publicado: (2014)

Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion
por: Rafacho, Alex, et al.
Publicado: (2015)

Zip4 Mediated Zinc Influx Stimulates Insulin Secretion in Pancreatic Beta Cells
por: Hardy, Alexandre B., et al.
Publicado: (2015)

Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion
por: Li, L, et al.
Publicado: (2016)

Calcium Channels in Postnatal Development of Rat Pancreatic Beta Cells and Their Role in Insulin Secretion
por: García-Delgado, Neivys, et al.
Publicado: (2018)

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion
por: Oberhauser, Lucie, et al.
Publicado: (2021)

Involvement of receptor-interacting protein 140 in palmitate-stimulated macrophage infiltration of pancreatic beta cells
por: Zou, Runmei, et al.
Publicado: (2017)

Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells
por: Blesia, Voni, et al.
Publicado: (2021)

Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion
por: El Azzouny, Mahmoud, et al.
Publicado: (2016)

Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β-Cells Treated with Palmitate and Oleate
por: Cataldo, L. R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7afvga7oq7ku62beo111tfl5jn