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Accumulation of Wildtype and ALS-Linked Mutated VAPB Impairs Activity of the Proteasome
Cellular homeostasis relies on a tight control of protein synthesis, folding and degradation, in which the endoplasmic reticulum (ER) quality control and the ubiquitin proteasome system (UPS) have an instrumental function. ER stress and aberrant accumulation of misfolded proteins represent a patholo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187839/ https://www.ncbi.nlm.nih.gov/pubmed/21998752 http://dx.doi.org/10.1371/journal.pone.0026066 |