3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

[Image: see text] Histone–lysine acetylation is a vital chromatin post-translational modification involved in the epigenetic regulation of gene transcription. Bromodomains bind acetylated lysines, acting as readers of the histone-acetylation code. Competitive inhibitors of this interaction have anti...

Descripción completa

Detalles Bibliográficos
Autores principales: Hewings, David S., Wang, Minghua, Philpott, Martin, Fedorov, Oleg, Uttarkar, Sagar, Filippakopoulos, Panagis, Picaud, Sarah, Vuppusetty, Chaitanya, Marsden, Brian, Knapp, Stefan, Conway, Stuart J., Heightman, Tom D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188285/
https://www.ncbi.nlm.nih.gov/pubmed/21851057
http://dx.doi.org/10.1021/jm200640v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188285/
https://www.ncbi.nlm.nih.gov/pubmed/21851057
http://dx.doi.org/10.1021/jm200640v

Ejemplares similares