APC15 drives the turnover of MCC-Cdc20 to make the Spindle Assembly Checkpoint responsive to kinetochore attachment

Faithful chromosome segregation during mitosis depends on the Spindle Assembly Checkpoint (SAC) that monitors kinetochore attachment to the mitotic spindle. Unattached kinetochores generate mitotic checkpoint proteins complexes (MCCs) that bind and inhibit the Anaphase Promoting Complex/Cyclosome (A...

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Detalles Bibliográficos
Autores principales: Mansfeld, Jörg, Collin, Philippe, Collins, Mark O., Choudhary, Jyoti S., Pines, Jonathon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188299/
https://www.ncbi.nlm.nih.gov/pubmed/21926987
http://dx.doi.org/10.1038/ncb2347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188299/
https://www.ncbi.nlm.nih.gov/pubmed/21926987
http://dx.doi.org/10.1038/ncb2347

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