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Noninfectious Retrovirus Particles Drive the Apobec3/Rfv3 Dependent Neutralizing Antibody Response

Members of the APOBEC3 family of deoxycytidine deaminases counteract a broad range of retroviruses in vitro through an indirect mechanism that requires virion incorporation and inhibition of reverse transcription and/or hypermutation of minus strand transcripts in the next target cell. The selective...

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Detalles Bibliográficos
Autores principales: Smith, Diana S., Guo, Kejun, Barrett, Bradley S., Heilman, Karl J., Evans, Leonard H., Hasenkrug, Kim J., Greene, Warner C., Santiago, Mario L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188525/
https://www.ncbi.nlm.nih.gov/pubmed/21998583
http://dx.doi.org/10.1371/journal.ppat.1002284