Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast

Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous mutation and facilitates cellular adaptation. However, double mutants are inviable, suggesting that extreme mutation rates exceed an error thresho...

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Detalles Bibliográficos
Autores principales: Herr, Alan J., Ogawa, Masanori, Lawrence, Nicole A., Williams, Lindsey N., Eggington, Julie M., Singh, Mallika, Smith, Robert A., Preston, Bradley D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188538/
https://www.ncbi.nlm.nih.gov/pubmed/22022273
http://dx.doi.org/10.1371/journal.pgen.1002282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188538/
https://www.ncbi.nlm.nih.gov/pubmed/22022273
http://dx.doi.org/10.1371/journal.pgen.1002282

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