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Activity Deprivation Induces Neuronal Cell Death: Mediation by Tissue-Type Plasminogen Activator
Spontaneous activity is an essential attribute of neuronal networks and plays a critical role in their development and maintenance. Upon blockade of activity with tetrodotoxin (TTX), neurons degenerate slowly and die in a manner resembling neurodegenerative diseases-induced neuronal cell death. The...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188552/ https://www.ncbi.nlm.nih.gov/pubmed/21998719 http://dx.doi.org/10.1371/journal.pone.0025919 |