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Age-Specific Incidence Data Indicate Four Mutations Are Required for Human Testicular Cancers

Normal human cells require a series of genetic alterations to undergo malignant transformation. Direct sequencing of human tumors has identified hundreds of mutations in tumors, but many of these are thought to be unnecessary and a result of, rather than a cause of, the tumor. The exact number of mu...

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Detalles Bibliográficos
Autor principal: Brody, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188587/
https://www.ncbi.nlm.nih.gov/pubmed/21998737
http://dx.doi.org/10.1371/journal.pone.0025978