Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria

BACKGROUND: 4-hydroxy-2-oxoglutarate (HOG) aldolase is a unique enzyme in the hydroxyproline degradation pathway catalyzing the cleavage of HOG to pyruvate and glyoxylate. Mutations in this enzyme are believed to be associated with the excessive production of oxalate in primary hyperoxaluria type 3...

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Detalles Bibliográficos
Autores principales: Riedel, Travis J., Johnson, Lynnette C., Knight, John, Hantgan, Roy R., Holmes, Ross P., Lowther, W. Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188589/
https://www.ncbi.nlm.nih.gov/pubmed/21998747
http://dx.doi.org/10.1371/journal.pone.0026021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188589/
https://www.ncbi.nlm.nih.gov/pubmed/21998747
http://dx.doi.org/10.1371/journal.pone.0026021

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