Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma

BACKGROUND: GSK-3β phosphorylates numerous substrates that govern cell survival. It phosphorylates p53, for example, and induces its nuclear export, HDM2-dependent ubiquitination, and proteasomal degradation. GSK-3β can either enhance or inhibit programmed cell death, depending on the nature of the...

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Detalles Bibliográficos
Autores principales: Liu, Qingjun, Mier, James W, Panka, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189171/
https://www.ncbi.nlm.nih.gov/pubmed/21929745
http://dx.doi.org/10.1186/1476-4598-10-115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189171/
https://www.ncbi.nlm.nih.gov/pubmed/21929745
http://dx.doi.org/10.1186/1476-4598-10-115

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