Neuronal Nitric Oxide Synthase-Rescue of Dystrophin/Utrophin Double Knockout Mice does not Require nNOS Localization to the Cell Membrane

Survival of dystrophin/utrophin double-knockout (dko) mice was increased by muscle-specific expression of a neuronal nitric oxide synthase (nNOS) transgene. Dko mice expressing the transgene (nNOS TG+/dko) experienced delayed onset of mortality and increased life-span. The nNOS TG+/dko mice demonstr...

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Detalles Bibliográficos
Autores principales: Wehling-Henricks, Michelle, Tidball, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189177/
https://www.ncbi.nlm.nih.gov/pubmed/22003386
http://dx.doi.org/10.1371/journal.pone.0025071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189177/
https://www.ncbi.nlm.nih.gov/pubmed/22003386
http://dx.doi.org/10.1371/journal.pone.0025071

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