Ligand-Directed Functional Selectivity at the Mu Opioid Receptor Revealed by Label-Free Integrative Pharmacology On-Target

Development of new opioid drugs that provide analgesia without producing dependence is important for pain treatment. Opioid agonist drugs exert their analgesia effects primarily by acting at the mu opioid receptor (MOR) sites. High-resolution differentiation of opioid ligands is crucial for the deve...

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Detalles Bibliográficos
Autores principales: Morse, Megan, Tran, Elizabeth, Sun, Haiyan, Levenson, Robert, Fang, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189208/
https://www.ncbi.nlm.nih.gov/pubmed/22003401
http://dx.doi.org/10.1371/journal.pone.0025643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189208/
https://www.ncbi.nlm.nih.gov/pubmed/22003401
http://dx.doi.org/10.1371/journal.pone.0025643

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