Cargando…

Binding-Folding Induced Regulation of AF1 Transactivation Domain of the Glucocorticoid Receptor by a Cofactor That Binds to Its DNA Binding Domain

Intrinsically disordered (ID) regions of proteins commonly exist within transcription factors, including the N-terminal domain (NTD) of steroid hormone receptors (SHRs) that possesses a powerful activation function, AF1 region. The mechanisms by which SHRs pass signals from a steroid hormone to cont...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garza, Anna S., Khan, Shagufta H., Moure, Carmen M., Edwards, Dean P., Kumar, Raj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189220/ https://www.ncbi.nlm.nih.gov/pubmed/22003412 http://dx.doi.org/10.1371/journal.pone.0025875

Ejemplares similares

TBP Binding-Induced Folding of the Glucocorticoid Receptor AF1 Domain Facilitates Its Interaction with Steroid Receptor Coactivator-1
por: Khan, Shagufta H., et al.
Publicado: (2011)

Remarkably Fast Coupled Folding and Binding of the Intrinsically Disordered Transactivation Domain of cMyb to CBP KIX
por: Shammas, Sarah L., et al.
Publicado: (2013)

NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain
por: Vise, Pamela D., et al.
Publicado: (2005)

Estrogen receptor transcription and transactivation: Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors
por: Ruff, Marc, et al.
Publicado: (2000)

The Lid Domain of Caenorhabditis elegans Hsc70 Influences ATP Turnover, Cofactor Binding and Protein Folding Activity
por: Sun, Li, et al.
Publicado: (2012)

Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator
por: Jeffery, Heather M., et al.
Publicado: (2020)

Conformational Control of the Binding of the Transactivation Domain of the MLL Protein and c-Myb to the KIX Domain of CREB
por: Korkmaz, Elif Nihal, et al.
Publicado: (2012)

Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25
por: Landrieu, Isabelle, et al.
Publicado: (2015)

SH2 Domains: Folding, Binding and Therapeutical Approaches
por: Diop, Awa, et al.
Publicado: (2022)

The AF-2 cofactor binding region is key for the selective SUMOylation of estrogen receptor alpha by antiestrogens
por: Vallet, Amandine, et al.
Publicado: (2022)

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin
por: Lim, Michael, et al.
Publicado: (2019)

Modulation of p53 Transactivation Domain Conformations by Ligand Binding and Cancer-Associated Mutations
por: Liu, Xiaorong, et al.
Publicado: (2020)

p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
por: Usluer, Sinem, et al.
Publicado: (2021)

The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment
por: Parrini, Matthias, et al.
Publicado: (2018)

Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex
por: Siggers, Trevor, et al.
Publicado: (2011)

Folding and Binding Mechanisms of the SH2 Domain from Crkl
por: Nardella, Caterina, et al.
Publicado: (2022)

Phylogenetic Analysis with Prediction of Cofactor or Ligand Binding for Pseudomonas aeruginosa PAS and Cache Domains
por: Hutchin, Andrew, et al.
Publicado: (2021)

Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding
por: Andresen, Cecilia, et al.
Publicado: (2012)

DNA-dependent protein kinase catalytic subunit binds to the transactivation domain 1 of NF-κB p65
por: Hasegawa, Yuta, et al.
Publicado: (2023)

The Clathrin-Binding Domain of CALM-AF10 Alters the Phenotype of Myeloid Neoplasms in Mice
por: Stoddart, Angela, et al.
Publicado: (2011)

An NMR study on the intrinsically disordered core transactivation domain of human glucocorticoid receptor
por: Kim, Do-Hyoung, et al.
Publicado: (2017)

The transition state structure for coupled binding and folding of disordered protein domains
por: Dogan, Jakob, et al.
Publicado: (2013)

Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major
por: Barrack, Keri L., et al.
Publicado: (2015)

Solution structure and binding specificity of the p63 DNA binding domain
por: Enthart, Andreas, et al.
Publicado: (2016)

Site-specific phosphorylation regulates the structure and function of an intrinsically disordered domain of the glucocorticoid receptor
por: Khan, Shagufta H., et al.
Publicado: (2017)

Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain
por: Suzuki, Shiori, et al.
Publicado: (2020)

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding
por: Starr, Tyler N., et al.
Publicado: (2020)

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
por: Starr, Tyler N., et al.
Publicado: (2020)

Novel DNA-binding element within the C-terminal extension of the nuclear receptor DNA-binding domain
por: Jakób, Michał, et al.
Publicado: (2007)

Redefining the DNA-Binding Domain of Human XPA
por: Sugitani, Norie, et al.
Publicado: (2014)

The middle lipin domain adopts a membrane-binding dimeric protein fold
por: Gu, Weijing, et al.
Publicado: (2021)

Interdiction in the Early Folding of the p53 DNA-Binding Domain Leads to Its Amyloid-Like Misfolding
por: Bergasa-Caceres, Fernando, et al.
Publicado: (2022)

Naturally Occurring Osmolyte, Trehalose Induces Functional Conformation in an Intrinsically Disordered Activation Domain of Glucocorticoid Receptor
por: Khan, Shagufta H., et al.
Publicado: (2011)

Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery
por: Vaccaro, Francesca A., et al.
Publicado: (2023)

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A
por: Glanzer, Jason G., et al.
Publicado: (2013)

Crystal Structure of the Mineralocorticoid Receptor DNA Binding Domain in Complex with DNA
por: Hudson, William H., et al.
Publicado: (2014)

A Substitution in the Ligand Binding Domain of the Porcine Glucocorticoid Receptor Affects Activity of the Adrenal Gland
por: Murani, Eduard, et al.
Publicado: (2012)

The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor
por: Frank, Filipp, et al.
Publicado: (2018)

The Thalidomide-Binding Domain of Cereblon Defines the CULT Domain Family and Is a New Member of the β-Tent Fold
por: Lupas, Andrei N., et al.
Publicado: (2015)

An extended U2AF(65)–RNA-binding domain recognizes the 3′ splice site signal
por: Agrawal, Anant A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_o9h4r1hbe2lu06stf1hmpttpnn