Thermodynamically Stable RNA three-way junctions as platform for constructing multi-functional nanoparticles for delivery of therapeutics

RNA nanoparticles can potentially be used to treat cancers and viral infection but their instability has hindered their therapeutic applications. The lack of covalent linkage or cross-linking in the nanoparticles causes dissociation in vivo. Here we show the assembly of thermodynamically stable thre...

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Detalles Bibliográficos
Autores principales: Shu, Dan, Shu, Yi, Haque, Farzin, Abdelmawla, Sherine, Guo, Peixuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189281/
https://www.ncbi.nlm.nih.gov/pubmed/21909084
http://dx.doi.org/10.1038/nnano.2011.105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189281/
https://www.ncbi.nlm.nih.gov/pubmed/21909084
http://dx.doi.org/10.1038/nnano.2011.105

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