Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation

Acylpeptide hydrolase (APEH), one of the four members of the prolyl oligopeptidase class, catalyses the removal of N-acylated amino acids from acetylated peptides and it has been postulated to play a key role in protein degradation machinery. Disruption of protein turnover has been established as an...

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Detalles Bibliográficos
Autores principales: Palmieri, Gianna, Bergamo, Paolo, Luini, Alberto, Ruvo, Menotti, Gogliettino, Marta, Langella, Emma, Saviano, Michele, Hegde, Ramanath N., Sandomenico, Annamaria, Rossi, Mose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189933/
https://www.ncbi.nlm.nih.gov/pubmed/22016782
http://dx.doi.org/10.1371/journal.pone.0025888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189933/
https://www.ncbi.nlm.nih.gov/pubmed/22016782
http://dx.doi.org/10.1371/journal.pone.0025888

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