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Gnarled-Trunk Evolutionary Model of Influenza A Virus Hemagglutinin
Human influenza A viruses undergo antigenic changes with gradual accumulation of amino acid substitutions on the hemagglutinin (HA) molecule. A strong antigenic mismatch between vaccine and epidemic strains often requires the replacement of influenza vaccines worldwide. To establish a practical mode...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189952/ https://www.ncbi.nlm.nih.gov/pubmed/22028800 http://dx.doi.org/10.1371/journal.pone.0025953 |