Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

BACKGROUND: Poly(ADP-ribose) polymerase (PARP)facilitates DNA repair and PARP inhibitors may potentiate the effect of DNA-damaging chemotherapeutic agents in patients with cancer. Collection of peripheral blood mononuclear cells (PBMCs)as a surrogate tissue to monitor PARP inhibitor pharmacodynamic...

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Detalles Bibliográficos
Autores principales: Ji, Jiuping, Kinders, Robert J., Zhang, Yiping, Rubinstein, Larry, Kummar, Shivaani, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189959/
https://www.ncbi.nlm.nih.gov/pubmed/22028822
http://dx.doi.org/10.1371/journal.pone.0026152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189959/
https://www.ncbi.nlm.nih.gov/pubmed/22028822
http://dx.doi.org/10.1371/journal.pone.0026152

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