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Human Siglec-5 Inhibitory Receptor and Immunoglobulin A (IgA) Have Separate Binding Sites in Streptococcal β Protein

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are receptors believed to be important for regulation of cellular activation and inflammation. Several pathogenic microbes bind specific Siglecs via sialic acid-containing structures at the microbial surface, interactions that may result in m...

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Detalles Bibliográficos
Autores principales: Nordström, Therése, Movert, Elin, Olin, Anders I., Ali, Syed R., Nizet, Victor, Varki, Ajit, Areschoug, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190825/
https://www.ncbi.nlm.nih.gov/pubmed/21795693
http://dx.doi.org/10.1074/jbc.M111.251728