Elimination of Proliferating Cells Unmasks the Shift from Senescence to Quiescence Caused by Rapamycin

BACKGROUND: Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. In cell lines with incomplete responses to p53, this shift may...

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Detalles Bibliográficos
Autores principales: Leontieva, Olga V., Demidenko, Zoya N., Gudkov, Andrei V., Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191182/
https://www.ncbi.nlm.nih.gov/pubmed/22022534
http://dx.doi.org/10.1371/journal.pone.0026126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191182/
https://www.ncbi.nlm.nih.gov/pubmed/22022534
http://dx.doi.org/10.1371/journal.pone.0026126

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