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Elimination of Proliferating Cells Unmasks the Shift from Senescence to Quiescence Caused by Rapamycin
BACKGROUND: Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. In cell lines with incomplete responses to p53, this shift may...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191182/ https://www.ncbi.nlm.nih.gov/pubmed/22022534 http://dx.doi.org/10.1371/journal.pone.0026126 |