Cargando…

Low Expression Of PP2A Regulatory Subunit B55α Is Associated With T308 Phosphorylation Of AKT And Shorter Complete Remission Duration In Acute Myeloid Leukemia Patients

The regulation of Protein Kinase B (AKT) is a dynamic process that depends on the balance between phosphorylation by upstream kinases for activation and inactivation by dephosphorylation by protein phosphatases. Phosphorylated AKT is commonly found in acute myeloid leukemia (AML) and confers an unfa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruvolo, Peter P., Qui, YiHua, Coombes, Kevin R., Zhang, Nianxiang, Ruvolo, Vivian R., Borthakur, Gautam, Konopleva, Marina, Andreeff, Michael, Kornblau, Steven M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191228/ https://www.ncbi.nlm.nih.gov/pubmed/21660042 http://dx.doi.org/10.1038/leu.2011.146

Ejemplares similares

Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients
por: Ruvolo, Peter P., et al.
Publicado: (2015)

MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation
por: Borthakur, Gautam, et al.
Publicado: (2015)

LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML
por: Ruvolo, Peter P., et al.
Publicado: (2019)

Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival
por: Kornblau, Steven M., et al.
Publicado: (2018)

Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia
por: Jacamo, Rodrigo, et al.
Publicado: (2017)

Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through the inhibition of autophagy
por: Zhang, Weiguo, et al.
Publicado: (2022)

The Interplay between PP2A and microRNAs in Leukemia
por: Ruvolo, Peter P.
Publicado: (2015)

Editorial: The Emerging Role for PP2A in Hematologic Malignancies
por: Ruvolo, Peter P.
Publicado: (2016)

Bone marrow stromal cells induce an ALDH(+) stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway
por: Yuan, Bin, et al.
Publicado: (2020)

The broken “Off” switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance
por: Ruvolo, Peter P.
Publicado: (2016)

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network
por: Carter, Bing Z., et al.
Publicado: (2016)

Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial
por: Zhang, Weiguo, et al.
Publicado: (2018)

Proteomic Profiling Identifies Distinct Protein Patterns in Acute Myelogenous Leukemia CD34+CD38- Stem-Like Cells
por: Kornblau, Steven M., et al.
Publicado: (2013)

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms
por: Ruvolo, Peter P., et al.
Publicado: (2017)

Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL
por: Piya, Sujan, et al.
Publicado: (2022)

Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34(+) proliferating and quiescent chronic myeloid leukemia blast crisis cells
por: Carter, Bing Z., et al.
Publicado: (2015)

Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine
por: Tabe, Yoko, et al.
Publicado: (2018)

Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest
por: Shouse, Geoffrey, et al.
Publicado: (2016)

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill F LT 3-ITD acute myeloid leukemia
por: Post, Sean M., et al.
Publicado: (2021)

Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs
por: Ishizawa, Jo, et al.
Publicado: (2015)

First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
por: Daver, Naval, et al.
Publicado: (2020)

Role for PKC δ in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells
por: Ruvolo, Vivian R., et al.
Publicado: (2010)

Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
por: Carter, Bing Z., et al.
Publicado: (2023)

Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
por: Carter, Bing Z., et al.
Publicado: (2023)

Shorter spontaneous fixation durations in infants with later emerging autism
por: Wass, Sam V., et al.
Publicado: (2015)

The Herculean task of killing cancer cells: Suppression of FOXO3A in acute leukemia involves a hydra of multiple survival kinases
por: Ruvolo, Peter P.
Publicado: (2012)

Addressing Mental Health Concerns in Refugees and Displaced Populations: Is Enough Being Done?
por: Grasser, Lana Ruvolo
Publicado: (2022)

Shorter respiratory event duration is related to prevalence of type 2 diabetes
por: Guo, Junwei, et al.
Publicado: (2023)

Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and re-sensitizes acute myeloid leukemia to BCL-2 inhibition
por: Carter, Bing Z., et al.
Publicado: (2020)

High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia
por: Zeng, Zhihong, et al.
Publicado: (2017)

PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells
por: Ozpolat, Bulent, et al.
Publicado: (2012)

Sustained MRD negative remission in del17p and TP53 mutated B cell prolymphocytic leukemia with ibrutinib and venetoclax
por: Siddiqui, Maria Tariq, et al.
Publicado: (2021)

Duration of anti-SARS-CoV-2 antibodies much shorter in India
por: Kumar, Nishant, et al.
Publicado: (2021)

Identification of the Adenovirus E4orf4 Protein Binding Site on the B55α and Cdc55 Regulatory Subunits of PP2A: Implications for PP2A Function, Tumor Cell Killing and Viral Replication
por: Mui, Melissa Z., et al.
Publicado: (2013)

Shorter mothers have shorter pregnancies
por: Derraik, José, et al.
Publicado: (2015)

Virtual Arts and Movement Therapies for Youth in the Era of COVID-19
por: Grasser, Lana Ruvolo, et al.
Publicado: (2021)

Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19
por: Padi, Sathish K.R., et al.
Publicado: (2023)

Corneal Cross-Linking: Evaluating the Potential for a Lower Power, Shorter Duration Treatment
por: Caruso, Ciro, et al.
Publicado: (2016)

Shorter sleep duration and better sleep quality are associated with greater tissue density in the brain
por: Takeuchi, Hikaru, et al.
Publicado: (2018)

Young age and shorter duration of Crohn’s disease are associated with non-adherence to taking medication
por: Yilmaz, Hasan
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ae7jikbtqpqtvggbaglc64me58