Abrogation of Cbl–PI3K Interaction Increases Bone Formation and Osteoblast Proliferation

Cbl is an adaptor protein and E3 ligase that plays both positive and negative roles in several signaling pathways that affect various cellular functions. Tyrosine 737 is unique to Cbl and phosphorylated by Src family kinases. Phosphorylated CblY737 creates a binding site for the p85 regulatory subun...

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Detalles Bibliográficos
Autores principales: Brennan, Tracy, Adapala, Naga Suresh, Barbe, Mary F., Yingling, Vanessa, Sanjay, Archana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191294/
https://www.ncbi.nlm.nih.gov/pubmed/21952831
http://dx.doi.org/10.1007/s00223-011-9531-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191294/
https://www.ncbi.nlm.nih.gov/pubmed/21952831
http://dx.doi.org/10.1007/s00223-011-9531-z

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