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Abrogation of Cbl–PI3K Interaction Increases Bone Formation and Osteoblast Proliferation
Cbl is an adaptor protein and E3 ligase that plays both positive and negative roles in several signaling pathways that affect various cellular functions. Tyrosine 737 is unique to Cbl and phosphorylated by Src family kinases. Phosphorylated CblY737 creates a binding site for the p85 regulatory subun...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191294/ https://www.ncbi.nlm.nih.gov/pubmed/21952831 http://dx.doi.org/10.1007/s00223-011-9531-z |