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Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage

BACKGROUND: The use and benefits of normobaric oxygen (NBO) in patients suffering acute ischemic stroke is still controversial. RESULTS: Here we show for the first time to the best of our knowledge that NBO reduces both NMDA-induced calcium influxes in vitro and NMDA-induced neuronal degeneration in...

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Autores principales: Haelewyn, Benoit, Chazalviel, Laurent, Nicole, Olivier, Lecocq, Myriam, Risso, Jean-Jacques, Abraini, Jacques H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191484/
https://www.ncbi.nlm.nih.gov/pubmed/22146487
http://dx.doi.org/10.1186/2045-9912-1-2
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author Haelewyn, Benoit
Chazalviel, Laurent
Nicole, Olivier
Lecocq, Myriam
Risso, Jean-Jacques
Abraini, Jacques H
author_facet Haelewyn, Benoit
Chazalviel, Laurent
Nicole, Olivier
Lecocq, Myriam
Risso, Jean-Jacques
Abraini, Jacques H
author_sort Haelewyn, Benoit
collection PubMed
description BACKGROUND: The use and benefits of normobaric oxygen (NBO) in patients suffering acute ischemic stroke is still controversial. RESULTS: Here we show for the first time to the best of our knowledge that NBO reduces both NMDA-induced calcium influxes in vitro and NMDA-induced neuronal degeneration in vivo, but increases oxygen and glucose deprivation-induced cell injury in vitro and ischemia-induced brain damage produced by middle cerebral artery occlusion in vivo. CONCLUSIONS: Taken together, these results indicate that NBO reduces excitotoxin-induced calcium influx and subsequent neuronal degeneration but favors ischemia-induced brain damage and neuronal death. These findings highlight the complexity of the mechanisms involved by the use of NBO in patients suffering acute ischemic stroke.
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spelling pubmed-31914842011-12-01 Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage Haelewyn, Benoit Chazalviel, Laurent Nicole, Olivier Lecocq, Myriam Risso, Jean-Jacques Abraini, Jacques H Med Gas Res Research BACKGROUND: The use and benefits of normobaric oxygen (NBO) in patients suffering acute ischemic stroke is still controversial. RESULTS: Here we show for the first time to the best of our knowledge that NBO reduces both NMDA-induced calcium influxes in vitro and NMDA-induced neuronal degeneration in vivo, but increases oxygen and glucose deprivation-induced cell injury in vitro and ischemia-induced brain damage produced by middle cerebral artery occlusion in vivo. CONCLUSIONS: Taken together, these results indicate that NBO reduces excitotoxin-induced calcium influx and subsequent neuronal degeneration but favors ischemia-induced brain damage and neuronal death. These findings highlight the complexity of the mechanisms involved by the use of NBO in patients suffering acute ischemic stroke. BioMed Central 2011-04-27 /pmc/articles/PMC3191484/ /pubmed/22146487 http://dx.doi.org/10.1186/2045-9912-1-2 Text en Copyright ©2011 Haelewyn et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Haelewyn, Benoit
Chazalviel, Laurent
Nicole, Olivier
Lecocq, Myriam
Risso, Jean-Jacques
Abraini, Jacques H
Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage
title Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage
title_full Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage
title_fullStr Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage
title_full_unstemmed Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage
title_short Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage
title_sort moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191484/
https://www.ncbi.nlm.nih.gov/pubmed/22146487
http://dx.doi.org/10.1186/2045-9912-1-2
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