RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation

BACKGROUND: β-Amyloid protein (Aβ) has been shown to potentiate the caspase-3 activation induced by the commonly used inhalation anesthetic isoflurane. However, it is unknown whether reduction in Aβ levels can attenuate the isoflurane-induced caspase-3 activation. We therefore set out to determine t...

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Detalles Bibliográficos
Autores principales: Dong, Yuanlin, Xu, Zhipeng, Zhang, Yiying, McAuliffe, Sayre, Wang, Hui, Shen, Xia, Yue, Yun, Xie, Zhongcong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191487/
https://www.ncbi.nlm.nih.gov/pubmed/22146340
http://dx.doi.org/10.1186/2045-9912-1-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191487/
https://www.ncbi.nlm.nih.gov/pubmed/22146340
http://dx.doi.org/10.1186/2045-9912-1-5

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