Meeting the demand for more sophisticated study designs. A proposal for a new type of clinical trial: the hybrid design

BACKGROUND: Treatment effect is traditionally assessed through either superiority or non-inferiority clinical trials. Investigators may find that because of safety concerns and/or wide variability across strata of the superiority margin of active controls over placebo, neither a superiority nor a no...

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Detalles Bibliográficos
Autores principales: Soon, Guoxing G, Nie, Lei, Hammerstrom, Thomas, Zeng, Wen, Chu, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2011
Materias:
Research Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191591/
https://www.ncbi.nlm.nih.gov/pubmed/22021876
http://dx.doi.org/10.1136/bmjopen-2011-000156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191591/
https://www.ncbi.nlm.nih.gov/pubmed/22021876
http://dx.doi.org/10.1136/bmjopen-2011-000156

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