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Meeting the demand for more sophisticated study designs. A proposal for a new type of clinical trial: the hybrid design
BACKGROUND: Treatment effect is traditionally assessed through either superiority or non-inferiority clinical trials. Investigators may find that because of safety concerns and/or wide variability across strata of the superiority margin of active controls over placebo, neither a superiority nor a no...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BMJ Group
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191591/ https://www.ncbi.nlm.nih.gov/pubmed/22021876 http://dx.doi.org/10.1136/bmjopen-2011-000156 |