Crystallographic Snapshots of Tyrosine Phenol-lyase Show That Substrate Strain Plays a Role in C–C Bond Cleavage

[Image: see text] The key step in the enzymatic reaction catalyzed by tyrosine phenol-lyase (TPL) is reversible cleavage of the Cβ–Cγ bond of l-tyrosine. Here, we present X-ray structures for two enzymatic states that form just before and after the cleavage of the carbon–carbon bond. As for most oth...

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Detalles Bibliográficos
Autores principales: Milić, Dalibor, Demidkina, Tatyana V., Faleev, Nicolai G., Phillips, Robert S., Matković-Čalogović, Dubravka, Antson, Alfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191766/
https://www.ncbi.nlm.nih.gov/pubmed/21899319
http://dx.doi.org/10.1021/ja203361g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191766/
https://www.ncbi.nlm.nih.gov/pubmed/21899319
http://dx.doi.org/10.1021/ja203361g

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