p53 Family: Role of Protein Isoforms in Human Cancer

TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Thei...

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Detalles Bibliográficos
Autores principales: Wei, Jinxiong, Zaika, Elena, Zaika, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191818/
https://www.ncbi.nlm.nih.gov/pubmed/22007292
http://dx.doi.org/10.1155/2012/687359
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author Wei, Jinxiong
Zaika, Elena
Zaika, Alexander
author_facet Wei, Jinxiong
Zaika, Elena
Zaika, Alexander
author_sort Wei, Jinxiong
collection PubMed
description TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.
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spelling pubmed-31918182011-10-17 p53 Family: Role of Protein Isoforms in Human Cancer Wei, Jinxiong Zaika, Elena Zaika, Alexander J Nucleic Acids Review Article TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer. Hindawi Publishing Corporation 2012 2011-10-09 /pmc/articles/PMC3191818/ /pubmed/22007292 http://dx.doi.org/10.1155/2012/687359 Text en Copyright © 2012 Jinxiong Wei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wei, Jinxiong
Zaika, Elena
Zaika, Alexander
p53 Family: Role of Protein Isoforms in Human Cancer
title p53 Family: Role of Protein Isoforms in Human Cancer
title_full p53 Family: Role of Protein Isoforms in Human Cancer
title_fullStr p53 Family: Role of Protein Isoforms in Human Cancer
title_full_unstemmed p53 Family: Role of Protein Isoforms in Human Cancer
title_short p53 Family: Role of Protein Isoforms in Human Cancer
title_sort p53 family: role of protein isoforms in human cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191818/
https://www.ncbi.nlm.nih.gov/pubmed/22007292
http://dx.doi.org/10.1155/2012/687359
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